I have just started the fifth book and have half a mind to start the whole thing over, from book one. I've read varying posts about it, like this one on Exoskeleton. I've been reading the book for so long that I'd forgotten about the artist who cut off his hand. I would like to never be done with this book. (I felt the same way about Neil Gaiman's Sandman series, which never should've ended). What am I going to do with myself when it ends, huh? What will I think about then?
As a weird, weird, painful aside, let me tell you about something from 2666. I can't remember when or where this happens in the book, but I know two characters discuss the Medusa story. One of them talks about how Medusa was different than the other Gorgon sisters because she was mortal. Her mortality creates Pegasus (right?) and stops a sea monster from eating a beautiful virgin. Medusa is set apart from her sisters because she will die. Since the 13th anniversary of my sister's death recently passed, I can't help but wonder why Medusa's sisters thought less of the one they would lose. Anyway, 2666 is definitely one of those books you'll finish reading, but you'll never be done with it.